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Silent and Rare Disorder 

Hypophosphatasia (HPP) is a rare genetic disorder characterized by impaired mineralization (“calcification”) of bones and teeth. Problems occur because mineralization is how bones and teeth take up calcium and phosphorus required for proper hardness and strength. (Hypophosphatasia - NORD (National Organization for Rare Disorders) (

Synonyms of Hypophosphatasia

  • HPP

  • Rathbun disease

Subdivisions of Hypophosphatasia

  • hypophosphatasia, perinatal

  • hypophosphatasia, infantile

  • hypophosphatasia, childhood (mild versus severe)

  • hypophosphatasia, adult

  • odontohypophosphatasia

  • pseudohypophosphatasia

  • (Hypophosphatasia - NORD (National Organization for Rare Disorders) (

Hypophosphatasia Disorder
HPP Brief: Welcome
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